Pope Leo is set to make a significant return to his official duties this Wednesday, holding his first general audience with pilgrims at the Vatican since undergoing surgery to treat lung cancer. The 71-year-old pontiff, who had the lower lobe of his right lung removed on October 13, signaled his intention to gradually resume his responsibilities during a public appearance this past Sunday. This weekly tradition typically draws massive crowds to St. Peter’s Square, where the leader of the world's 1.4 billion Catholics usually travels among the faithful in the popemobile.

While medical professionals have described the operation as a success, questions remain regarding the long-term impact of the diagnosis on his 17-month papacy. Diagnosed with lung adenocarcinoma shortly after his election in May 2025, the Pope’s recovery remains a closely watched matter, particularly regarding his upcoming travel schedule. Although surgeons believe he could be ready for his planned late-November tour of Uruguay, Argentina, and Peru, Vatican officials have hinted that his itinerary may need to be adjusted to prioritize his health and recovery.